csbb ntu.edu.tw

CSB 國立台灣大學系統生物學研究中心

PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Telomerase is highly expressed in cancer and embryonic stem cells ESCs and implicated in controlling genome integrity, cancer formation and stemness. Previous studies identified that Krüppel-like transcription factor 4 KLF4 activates telomerase reverse transcriptase TERT expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates. Aging is characterized by .
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CSB 國立台灣大學系統生物學研究中心

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PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Telomerase is highly expressed in cancer and embryonic stem cells ESCs and implicated in controlling genome integrity, cancer formation and stemness. Previous studies identified that Krüppel-like transcription factor 4 KLF4 activates telomerase reverse transcriptase TERT expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates. Aging is characterized by .

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The site states the following, "PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells." I noticed that the web site also said " Telomerase is highly expressed in cancer and embryonic stem cells ESCs and implicated in controlling genome integrity, cancer formation and stemness." They also stated " Previous studies identified that Krüppel-like transcription factor 4 KLF4 activates telomerase reverse transcriptase TERT expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates. Aging is characterized by ."

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